Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2024; 30(6): 527-541
Published online Feb 14, 2024. doi: 10.3748/wjg.v30.i6.527
Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome
Xin Li, Li-Jiang Ji, Kai-Di Feng, Hua Huang, Mei-Rou Liang, Shi-Jin Cheng, Xiu-Dong Meng
Xin Li, Xiu-Dong Meng, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, Guizhou Province, China
Li-Jiang Ji, Hua Huang, Department of Anorectal Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu 215500, Jiangsu Province, China
Kai-Di Feng, Mei-Rou Liang, Shi-Jin Cheng, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Co-first authors: Xin Li and Li-Jiang Ji.
Author contributions: Li X and Ji LJ wrote the paper the paper, they are the co-first authors; Feng KD, Huang H, Liang MR, Cheng SJ performed the collected the data; Meng XD contributed to the review, and editing of the manuscript; all authors have read and approved the final manuscript.
Supported by Guizhou University of Traditional Chinese Medicine Doctoral Initiation Fund, No. 202306; and Changshu Municipal Science and Technology Bureau Supporting Project, No. CS202030.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiu-Dong Meng, PhD, Researcher, School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing Road, Huaxi District, Guiyang 550025, Guizhou Province, China.
Received: October 22, 2023
Peer-review started: October 22, 2023
First decision: November 20, 2023
Revised: November 21, 2023
Accepted: January 9, 2024
Article in press: January 9, 2024
Published online: February 14, 2024
Core Tip

Core Tip: Clarifying the regulatory circuits that control the abnormal immune state of the intestinal mucosa is essential for understanding ulcerative colitis (UC) pathogenesis and clinical management. The role of exosomes and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes in UC has been continuously highlighted in recent years. In this review, the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are summarized. Furthermore, an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are highlighted.