Circulating tumor DNA in liquid biopsy: Current diagnostic limitation

doi:10.3748/wjg.v30.i15.2175

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Apr 21, 2024; 30(15): 2175-2178
Published online Apr 21, 2024. doi: 10.3748/wjg.v30.i15.2175

Circulating tumor DNA in liquid biopsy: Current diagnostic limitation

Shi-Cai Liu

Shi-Cai Liu, School of Medical Information, Wannan Medical College, Wuhu 241002, Anhui Province, China

Author contributions: Liu SC conceived the theme, and prepared the manuscript. All authors have read and approved the version to be published.

Supported by Talent Scientific Research Start-up Foundation of Wannan Medical College, No. WYRCQD2023045.

Conflict-of-interest statement: The authors declare no competing interests.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Shi-Cai Liu, PhD, Academic Research, School of Medical Information, Wannan Medical College, No. 22 Wenchang West Road, Wuhu 241002, Anhui Province, China. liushicainj@163.com

Received: February 2, 2024
Peer-review started: February 2, 2024
First decision: February 29, 2024
Revised: March 7, 2024
Accepted: April 2, 2024
Article in press: April 2, 2024
Published online: April 21, 2024

Core Tip

Core Tip: Tumor liquid biopsy based on cell-free DNA detection has become a major hotspot in the field of tumor research in recent years. Circulating tumor DNA (ctDNA) is a DNA fragment that breaks down from cells in primary tumors or even new tumors formed by metastasis, and enters the peripheral circulation. ctDNA analysis provides a non-invasive method for cancer detection and monitoring, which is important for the management of clinical patients.