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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2023; 29(2): 390-409
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.390
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.390
Third-line and rescue therapy for refractory Helicobacter pylori infection: A systematic review
Pedro Vieira de Moraes Andrade, Yan Mosca Monteiro, Ethel Zimberg Chehter, Department of Gastroenterology, Faculdade de Medicina do ABC, Santo André 09060-650, SP, Brazil
Author contributions: de Moraes Andrade PV, Monteiro YM, and Chehter EZ conceived, designed, wrote, and revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pedro Vieira de Moraes Andrade, Academic Research, Department of Gastroenterology, Faculdade de Medicina do ABC, Av. Lauro Gomes 2000, Santo André 09060-650, SP, Brazil. pvieira.m.andrade@gmail.com
Received: August 12, 2022
Peer-review started: August 12, 2022
First decision: September 2, 2022
Revised: September 12, 2022
Accepted: December 1, 2022
Article in press: December 1, 2022
Published online: January 14, 2023
Peer-review started: August 12, 2022
First decision: September 2, 2022
Revised: September 12, 2022
Accepted: December 1, 2022
Article in press: December 1, 2022
Published online: January 14, 2023
Core Tip
Core Tip: The eradication of Helicobacter pylori is widely discussed given the high prevalence and incidence of its infection. Even with established criteria in the V Maastricht Consensus for the eradication of infection and treatment algorithms for choosing first-line and second-line therapeutic regimens, therapeutic failure is frequent. Therefore, establishing safe, effective, and accessible third-line and rescue therapies for patients in need of eradication is necessary in the management of such infection. Due to this need, the present systematic review performed a systematic review evaluating the efficacy and safety of rescue therapies against refractory Helicobacter pylori infection.