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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2023; 29(19): 2932-2949
Published online May 21, 2023. doi: 10.3748/wjg.v29.i19.2932
Published online May 21, 2023. doi: 10.3748/wjg.v29.i19.2932
TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor
Cheng-Ming Guo, Li Tang, Xu Li, Liu-Ye Huang, Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, China
Author contributions: Guo CM and Tang L contributed equally to this work; Guo CM and Tang L performed the data acquisition, drafted the manuscript and executed the in vitro experiments; Guo CM completed the statistical analyses; Guo CM and Li X executed the animal experiments; Huang LY designed the work and revised the manuscript.
Supported by National Natural Science Foundation of China , No. 81870453 .
Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by Ethics Committee of Yantai Yuhuangding Hospital,No.2019-410.
Institutional animal care and use committee statement: All animal experiments were approved by the Affiliated Yantai Yuhuangding Hospital of Qingdao University for Laboratory Animal Welfare and Ethical Review, No. 2022-A56.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All authors report having no relevant conflicts of interest for this article.
Data sharing statement: The data can be obtained from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liu-Ye Huang, Professor, Academic Research, Chief Doctor, Chief Physician, Research Scientist, Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 Yuhuangding East Road, Yantai 264000, Shandong Province, China. liuye_huang@163.com
Received: November 28, 2022
Peer-review started: November 28, 2022
First decision: February 15, 2023
Revised: March 6, 2023
Accepted: April 11, 2023
Article in press: April 11, 2023
Published online: May 21, 2023
Peer-review started: November 28, 2022
First decision: February 15, 2023
Revised: March 6, 2023
Accepted: April 11, 2023
Article in press: April 11, 2023
Published online: May 21, 2023
Core Tip
Core Tip: TATA-box-binding protein-associated factor 15 (TAF15) was upregulated in gastrointestinal stromal tumor (GIST) cells and tissues and was associated with a poor prognosis in GIST patients. TAF15 promotes cell proliferation and migration of GIST in vitro and tumor growth in vivo via the activation of the RAF1/MEK/ERK signaling pathway. Therefore, TAF15 is expected to be a novel potential molecular biomarker or therapeutic target of GIST.