Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2023; 29(15): 2222-2240
Published online Apr 21, 2023. doi: 10.3748/wjg.v29.i15.2222
Published online Apr 21, 2023. doi: 10.3748/wjg.v29.i15.2222
Intersections between innate immune response and gastric cancer development
Franz Villarroel-Espindola, Troy Ejsmentewicz, Roxana Gonzalez-Stegmaier, Roddy A Jorquera, Esteban Salinas, Translational Medicine Unit, Instituto Oncologico Fundacion Arturo Lopez Perez, Santiago 7500000, Metropolitan region, Chile
Author contributions: Villarroel-Espíndola F contributed to the conceptualization, methodology, original draft preparation, writing, reviewing, editing, supervision and funding acquisition; Ejsmentewicz T and Salinas E contributed to the writing of the original draft; González-Stegmaier R contributed to the writing of the original draft, reviewing, editing and visualization; Jorquera R contributed to the writing, reviewing, editing and visualization.
Supported by Instituto Oncológico Fundación Arturo López Pérez , Santiago, Chile; National Research and Development Agency of Chile (ANID) and National Fund for Scientific and Technological Development (FONDECYT) , No. 1221415 (to Villarroel-Espindola F) .
Conflict-of-interest statement: Dr. F. Villarroel-Espindola has received compensation from Ilico SpA. and Gebrax-Chile for consulting services. Other authors declare having no conflict of interests, neither real nor perceivable, in relation to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Franz Villarroel-Espindola, PhD, Director, Translational Medicine Unit, Instituto Oncologico Fundacion Arturo Lopez Perez, Rancagua 878, Providencia, Santiago 7500000, Metropolitan region, Chile. franz.villarroel@falp.org
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: October 20, 2022
Revised: November 7, 2022
Accepted: March 9, 2023
Article in press: March 9, 2023
Published online: April 21, 2023
Peer-review started: September 20, 2022
First decision: October 20, 2022
Revised: November 7, 2022
Accepted: March 9, 2023
Article in press: March 9, 2023
Published online: April 21, 2023
Core Tip
Core Tip: Premalignant cascade of gastric cancer starts with a chronic gastritis, and evolves to atrophic gastritis, intestinal metaplasia, dysplasia and finally the carcinoma. During the process, different immune responses contribute to inflammation of the gastric epithelium. Our work compiles studies related to the innate immune response with a focus on molecular and cellular features such as, Toll-like receptors, neutrophils, cytokines and socioeconomic factors, as crucial players during the precancerous cascade and the cancer onset.