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World J Gastroenterol. Jan 7, 2023; 29(1): 61-74
Published online Jan 7, 2023. doi: 10.3748/wjg.v29.i1.61
Evolution of care in cirrhosis: Preventing hepatic decompensation through pharmacotherapy
Seohyuk Lee, Saad Saffo
Seohyuk Lee, Saad Saffo, Department of Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, CT 06520-8019, United States
Author contributions: Lee S and Saffo S reviewed the literature and drafted the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Saad Saffo, MD, Academic Fellow, Department of Medicine, Section of Digestive Diseases, Yale School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06520-8019, United States.
Received: September 26, 2022
Peer-review started: September 26, 2022
First decision: October 18, 2022
Revised: October 22, 2022
Accepted: December 13, 2022
Article in press: December 13, 2022
Published online: January 7, 2023
Processing time: 100 Days and 5.5 Hours
Core Tip

Core Tip: Hepatic decompensation is the most important clinical predictor of morbidity and mortality among patients with cirrhosis. New pharmacotherapies aimed at preventing hepatic decompensation in high-risk patients are emerging, augmenting traditional management strategies. These treatments represent safe, accessible, and effective options that may improve quality of life and prolong transplant-free survival, regardless of the etiologic factors involved.