Jiang ZF, Wu W, Hu HB, Li ZY, Zhong M, Zhang L. P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption. World J Gastroenterol 2022; 28(36): 5265-5279 [PMID: 36185635 DOI: 10.3748/wjg.v28.i36.5265]
Corresponding Author of This Article
Lin Zhang, MD, PhD, Doctor, Center of Emergency & Intensive Care Unit, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Shanghai 201508, China. linzhang0315@fudan.edu.cn
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 28, 2022; 28(36): 5265-5279 Published online Sep 28, 2022. doi: 10.3748/wjg.v28.i36.5265
P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption
Zhi-Feng Jiang, Wei Wu, Han-Bing Hu, Zheng-Yang Li, Ming Zhong, Lin Zhang
Zhi-Feng Jiang, Han-Bing Hu, Lin Zhang, Center of Emergency & Intensive Care Unit, Jinshan Hospital of Fudan University, Shanghai 201508, China
Wei Wu, Ming Zhong, Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zheng-Yang Li, Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai 201508, China
Author contributions: Jiang ZF and Wu W contributed equally to this work; Zhong M and Zhang L were co-corresponding authors; Jiang ZF and Wu W wrote the manuscript; Zhang L and Zhong M conceived the topic and reviewed the manuscript; Jiang ZF and Zhang L revised the manuscript; Hu HB and Li ZY reviewed the manuscript; all authors contributed to the article and approved the submitted version.
Supported byThe National Natural Science Foundation of China, No. 81801943; Shanghai Pujiang Program, No. 21PJD009; and The Research Grant for Public Health Key Discipline of Shanghai Municipality, China, No. GWV-10.1-XK26.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Zhang, MD, PhD, Doctor, Center of Emergency & Intensive Care Unit, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Shanghai 201508, China. linzhang0315@fudan.edu.cn
Received: March 12, 2022 Peer-review started: March 12, 2022 First decision: June 11, 2022 Revised: June 20, 2022 Accepted: September 1, 2022 Article in press: September 1, 2022 Published online: September 28, 2022
Core Tip
Core Tip: Intestinal barrier dysfunction is usually accompanied by inflammation and the death of epithelial cells, which may lead to an elevated concentration of extracellular adenosine triphosphate and the intestinal immune response. Meanwhile, available studies have demonstrated that P2X7 receptor (P2X7R) can be an important regulatory factor in the activation and differentiation of T cells, suggesting that P2X7R may play a key role in intestinal barrier disruption by regulating T cells. Therefore, in this review, we summarized the recent advances regarding the intestinal barrier, the role of P2X7R and T-cells in the pathophysiology of intestinal barrier disruption, and the role of T cell-derived P2X7R in the pathophysiology of intestinal barrier dysfunction.
