Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

doi:10.3748/wjg.v28.i21.2302

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Jun 7, 2022 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Jun 7, 2022; 28(21): 2302-2319
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2302

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

Noel E Donlon, Maria Davern, Fiona O’Connell, Andrew Sheppard, Aisling Heeran, Anshul Bhardwaj, Christine Butler, Ravi Narayanasamy, Claire Donohoe, James J Phelan, Niamh Lynam-Lennon, Margaret R Dunne, Stephen Maher, Jacintha O’Sullivan, John V Reynolds, Joanne Lysaght

Author contributions: Donlon NE and Davern M contributed equally to this work; Donlon NE and Davern M contributed to experimental design and execution, and manuscript drafting and revision; O’Connell F and Sheppard A contributed to experiments; Heeran A, Bhardwaj A, and Butler C contributed to sample acquisition; Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, and Maher S contributed to concept design; Phelan JJ contributed to statistical analysis; O’Sullivan J, Reynolds JV, and Lysaght J contributed to paper revision and supervision of the project.

Institutional review board statement: The study was reviewed and approved by the Tallaght/St James’s Hospital Ethics Committee.

Conflict-of-interest statement: There are no conflicts of interest to report.

Data sharing statement: Data generated in this study will be available upon specific request from the corresponding author.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Noel E Donlon, MD, Assistant Professor, Department of Surgery, Trinity Translational Medicine Institute, St James Hospital, James’s Street, Dublin D08, Ireland. donlonn@tcd.ie

Received: December 3, 2021
Peer-review started: December 3, 2021
First decision: January 27, 2022
Revised: February 19, 2022
Accepted: April 26, 2022
Article in press: April 26, 2022
Published online: June 7, 2022

Core Tip

Core Tip: This body of work evaluates the impact of radiotherapy on the immune profile in oesophageal adenocarcinoma with an added caveat of immunotherapy effects on tumour cell killing.