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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2022; 28(16): 1705-1717
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1705
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1705
Risk of venous thromboembolism in children and adolescents with inflammatory bowel disease: A systematic review and meta-analysis
Xin-Yue Zhang, Hai-Cheng Dong, Wen-Fei Wang, Yao Zhang, Department of Traditional Chinese Medicine, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310005, Zhejiang Province, China
Author contributions: Wang CL, Liang L, Fu JF, Zou CC, Hong F and Wu XM designed the research; Wang CL, Zou CC, Hong F and Wu XM performed the research; Xue JZ and Lu JR contributed new reagents/analytic tools; Wang CL, Liang L and Fu JF analyzed the data; Wang CL, Liang L and Fu JF wrote the paper.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Yue Zhang, MM, Attending Doctor, Department of Traditional Chinese Medicine, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 57 Zhugan Lane, Xiancheng District, Hangzhou 310005, Zhejiang Province, China. cicelyxyz@zju.edu.cn
Received: August 19, 2021
Peer-review started: August 19, 2021
First decision: October 16, 2021
Revised: November 1, 2021
Accepted: March 27, 2022
Article in press: March 27, 2022
Published online: April 28, 2022
Peer-review started: August 19, 2021
First decision: October 16, 2021
Revised: November 1, 2021
Accepted: March 27, 2022
Article in press: March 27, 2022
Published online: April 28, 2022
Core Tip
Core Tip: This study suggested that child and adolescent inflammatory bowel disease (IBD) patients showed an increased risk of venous thrombotic events (VTE) (P = 0.02, 95%CI: 0.01-0.03). Subgroup analysis stratified by IBD (ulcerative colitis: P = 0.04, 95%CI: 0.03-0.06; Crohn’s disease: P = 0.02, 95%CI: 0.00-0.04) and VTE subtypes (portal vein thrombosis: P = 0.04, 95%CI: 0.02-0.06; deep vein thrombosis: P = 0.03, 95%CI: 0.01-0.05; central venous catheter-related thrombosis: P = 0.13, 95%CI: 0.02-0.23; thromboembolic events: P = 0.02, 95%CI: 0.01-0.03) revealed a significant correlation between VTE incidence and IBD.