Published online Apr 14, 2022. doi: 10.3748/wjg.v28.i14.1384
Peer-review started: December 5, 2021
First decision: January 8, 2022
Revised: January 9, 2022
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: April 14, 2022
Core Tip: Hepatocellular adenoma (HCA) has been well recognized as a benign liver neoplasm with risks of hemorrhage and malignant transformation. Studies revealed that different HCA subtypes with specific genetic mutation and pathologic findings are associated with different clinical features. Currently HCAs are classified into at least 5 major subtypes, involving 4 different pathways driving HCA pathogenesis: Hepatocyte nuclear factor 1A, interleukin-6/the Janus kinase/signal transducer and activator of transcription, β-catenin, and Sonic hedgehog pathway.