Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2022; 28(12): 1272-1283
Published online Mar 28, 2022. doi: 10.3748/wjg.v28.i12.1272
Epidemiological, clinical, and histological presentation of celiac disease in Northwest China
Man Wang, Wen-Jie Kong, Yan Feng, Jia-Jie Lu, Wen-Jia Hui, Wei-Dong Liu, Zi-Qiong Li, Tian Shi, Mei Cui, Zhen-Zhu Sun, Feng Gao
Man Wang, Wen-Jie Kong, Yan Feng, Jia-Jie Lu, Wen-Jia Hui, Wei-Dong Liu, Zi-Qiong Li, Tian Shi, Feng Gao, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Mei Cui, Zhen-Zhu Sun, Department of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Author contributions: Wang M and Gao F designed the study; Wang M, Kong WJ, and Lu JJ acquired the data and drafted the article; Hui WJ and Liu WD analyzed and interpreted the data; Cui M and Sun ZZ made a pathological diagnosis; Feng Y, Li ZQ, Shi T and Gao F revised the article critically for important intellectual content; all the authors approved the version to be published.
Supported by National Natural Science Foundation of China, No. 81760101; and Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2021D01C149.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of People’s Hospital of Xinjiang Uygur Autonomous Region.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Gao, PhD, Chairman, Chief Doctor, Director, Professor, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. drxjgf@sina.com
Received: September 12, 2021
Peer-review started: September 12, 2021
First decision: October 16, 2021
Revised: November 16, 2021
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: March 28, 2022
Core Tip

Core Tip: Celiac disease (CD) is an autoimmune disease caused by the ingestion of gluten in genetically susceptible individuals. The global prevalence of CD is approximately 1.4%. An increase in celiac-specific autoantibody levels can lead to varying degrees of damage to the small intestinal mucosa and consequently to various gastrointestinal and systemic symptoms. This study reports the epidemiological, clinical, and pathological characteristics of CD and its association with Helicobacter pylori infection and aims to provide useful information for the clinical diagnosis and treatment of CD.