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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2021; 27(9): 782-793
Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Interaction between hepatitis B virus and SARS-CoV-2 infections
Tian-Dan Xiang, Xin Zheng, Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Zheng X contributed to the conception and design of the work and revised the manuscript; Xiang TD performed the literature review and drafted the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Zheng, MD, PhD, Professor, Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. xin11@hotmail.com
Received: December 8, 2020
Peer-review started: December 8, 2020
First decision: December 31, 2020
Revised: January 11, 2021
Accepted: February 1, 2021
Article in press: February 1, 2021
Published online: March 7, 2021
Peer-review started: December 8, 2020
First decision: December 31, 2020
Revised: January 11, 2021
Accepted: February 1, 2021
Article in press: February 1, 2021
Published online: March 7, 2021
Core Tip
Core Tip: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has become a global public health crisis. Liver impairment is frequent in COVID-19 regardless of whether it is combined with hepatitis B virus (HBV) infection. Currently, there is no evidence to suggest that HBV increases susceptibility to SARS-CoV-2. HBV and SARS-CoV-2 coinfection does not increase the risk of severity and outcome of COVID-19. Nucleoside analogs are recommended due to the risk of HBV reactivation in COVID-19.