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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2021; 27(6): 470-486
Published online Feb 14, 2021. doi: 10.3748/wjg.v27.i6.470
Published online Feb 14, 2021. doi: 10.3748/wjg.v27.i6.470
Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells
Fu-Yong Li, Department of Interventional Radiology, Jinan City People's Hospital, Jinan 271100, Shandong Province, China
Ting-Yong Fan, Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Jinan 250117, Shandong Province, China
Hao Zhang, Department of Endoscopy, Shandong Cancer Hospital affiliated to Shandong University, Jinan 250117, Shandong Province, China
Yu-Min Sun, Department of Cardiology, Jinan City People's Hospital, Jinan 271100, Shandong Province, China
Author contributions: Li FY conceived the idea; Fan TY conducted the analyses; Zhang H and Sun YM provided the data; All authors contributed to the writing and revisions.
Institutional review board statement: The study was reviewed and approved by the Shandong Cancer Hospital affiliated to Shandong University.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Yong Fan, MD, Chief Physician, Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, No. 440 Jiyan Road, Jinan 250117, Shandong Province, China. fantcwq50216@163.com
Received: October 20, 2020
Peer-review started: October 20, 2020
First decision: December 8, 2020
Revised: December 21, 2020
Accepted: December 29, 2020
Article in press: December 29, 2020
Published online: February 14, 2021
Peer-review started: October 20, 2020
First decision: December 8, 2020
Revised: December 21, 2020
Accepted: December 29, 2020
Article in press: December 29, 2020
Published online: February 14, 2021
Core Tip
Core Tip: This study confirmed the relationship of microRNA 34a (miR-34a) hypermethylation with membrane palmitoylated protein (MPP2) expression by investigating the changes of biological function and MPP2 expression level of liver cancer cells after miR-34a demethylation. miR-34a can inhibit the occurrence of liver cancer by upregulating MPP2, and its demethylation in liver cancer cells is a potential method of liver cancer treatment. In essence, miR-34a methylation is located upstream of its binding site with p53. Therefore, it is valuable to study the role of miR-34a methylation/demethylation on the expression level of upstream regulatory factors such as p53, and to explore its function in the future.