Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2021; 27(46): 8010-8030
Published online Dec 14, 2021. doi: 10.3748/wjg.v27.i46.8010
Life prognosis of sentinel node navigation surgery for early-stage gastric cancer: Outcome of lymphatic basin dissection
Shinichi Kinami, Naohiko Nakamura, Tomoharu Miyashita, Hidekazu Kitakata, Sachio Fushida, Takashi Fujimura, Yasuo Iida, Noriyuki Inaki, Toru Ito, Hiroyuki Takamura
Shinichi Kinami, Naohiko Nakamura, Tomoharu Miyashita, Hiroyuki Takamura, Department of Surgical Oncology, Kanazawa Medical University, Kahoku 920-0293, Ishikawa, Japan
Hidekazu Kitakata, Toru Ito, Department of Gastroenterological Endoscopy, Kanazawa Medical University, Kahoku 920-0293, Ishikawa, Japan
Sachio Fushida, Noriyuki Inaki, Department of Gastrointestinal Surgery, Kanazawa University, Kanazawa 920-8641, Ishikawa, Japan
Takashi Fujimura, Department of Surgery, Toyama City Hospital, Toyama 939-8511, Toyama, Japan
Yasuo Iida, Department of Mathematics, Division of General Education, Kanazawa Medical University, Kahoku 920-0293, Ishikawa, Japan
Author contributions: Kinami S was responsible for the scientific conception of the study and writing of the manuscript; Kinami S, Nakamura N, Miyashita T, Kitakata H, Fushida S, Fujimura T, and Ito T contributed to the surgery and data collection; Iida Y was responsible for the statistical analysis; Takamura H and Inaki N contributed to the drafting, editing, and critical revision of the manuscript; and all authors contributed to the approval of the final version of the manuscript.
Institutional review board statement: This study was approved by the ethics committee of Kanazawa University Hospital and Kanazawa Medical University (Trial Number R093, M288). ICG mapping was approved by the ethics committee of Kanazawa Medical University (Trial Number M404).
Informed consent statement: All patients provided written informed consent for surgery and the use of their data. Regarding data use in the retrospective study, the patients were given the opportunity to opt out of the study at any time.
Conflict-of-interest statement: The authors declare no conflicts of interest related to the publication of this study.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Shinichi Kinami, MD, PhD, Professor, Department of Surgical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku 920-0293, Ishikawa, Japan.
Received: May 20, 2021
Peer-review started: May 20, 2021
First decision: June 22, 2021
Revised: June 28, 2021
Accepted: November 29, 2021
Article in press: November 29, 2021
Published online: December 14, 2021
Core Tip

Core Tip: The oncological safety of 239 patients with early-stage gastric cancer who underwent sentinel node navigation surgery was investigated. In total, 81.6% of patients underwent modified gastrectomy or function-preserving curative gastrectomy with lymphatic basin dissection, and the extent of nodal dissection was reduced compared to the guidelines. The overall survival rate at 5 years was significantly better, and the cumulative recurrence rate was equal to that of the control group in original data sets and propensity score-matched comparisons. The oncological safety of patients undergoing gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery.