Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome: A prospective multi-centre cohort study
Marianne Anastasia De Roza, Johnathan Huey-Ming Lum, Department of Gastroenterology and Hepatology, Sengkang General Hospital, Singhealth, Singapore 544886, Singapore
Mehul Lamba, Jing Hieng Jeffrey Ngu, Department of Gastroenterology and Hepatology, Christchurch Hospital, Christchurch 8011, New Zealand
George Boon-Bee Goh, Mark Chang-Chuen Cheah, Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore 169608, Singapore
George Boon-Bee Goh, Duke-NUS Medical School, Singapore 169608, Singapore
Author contributions: De Roza MA contributed to study design, data collection and analysis, manuscript writing, critical Review and submission of manuscript; Lamda M contributed to study design, data collection and analysis, manuscript writing and review of manuscript; Goh GBB contributed to study design and critical review of manuscript; Cheah MCC and Lum JHM contributed to data collection; Ngu JHJ contributed to study design, writing and critical review of manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: This study conforms to ethical guidelines and was approved by our institutional review board with waiver of patient consent.
Clinical trial registration statement: This study does not include any intervention and is not a randomized controlled trial.
Informed consent statement: Consent was not obtained as data was anonymized and protected with little to no risk of identification.
Conflict-of-interest statement: All authors declare there are no conflicts of interest. None of the authors received financial support or grants for this study.
Data sharing statement: Statistical code, and dataset is available from the corresponding author at firstname.lastname@example.org.
CONSORT 2010 statement: The manuscript was checked according to the CONSORT 2010.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Hieng Jeffrey Ngu, MBChB, FRACP, PhD, Academic Research, Consultant Physician-Scientist, Doctor, Department of Gastroenterology and Hepatology, Christchurch Hospital, Riccarton Avenue, Christchurch 8011, New Zealand. email@example.com
Received: April 19, 2021
Peer-review started: April 19, 2021
First decision: June 23, 2021
Revised: July 20, 2021
Accepted: November 2, 2021
Article in press: November 2, 2021
Published online: November 21, 2021