Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2021; 27(38): 6465-6475
Published online Oct 14, 2021. doi: 10.3748/wjg.v27.i38.6465
Magnetic resonance imaging-radiomics evaluation of response to chemotherapy for synchronous liver metastasis of colorectal cancer
Yan-Qing Ma, Yang Wen, Hong Liang, Jian-Guo Zhong, Pei-Pei Pang
Yan-Qing Ma, Yang Wen, Jian-Guo Zhong, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou 310000, Zhejiang Province, China
Hong Liang, Department of Radiology, Hangzhou Medical College, Hangzhou 310000, Zhejiang Province, China
Pei-Pei Pang, Department of Pharmaceuticals Diagnosis, GE Healthcare, Hangzhou 310000, Zhejiang Province, China
Author contributions: Ma YQ designed the retrospective study and wrote the original article; Wen Y directed and coordinated the study; Zhong JG and Liang H performed a part of the study; Pang PP analyzed the data; All authors have read and approve the final manuscript.
Supported by The fund of Medical and Health Research Projects of Health Commission of Zhejiang Province, No. 2019KY035.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Zhejiang Provincial People’s Hospital, No. 2020QT251.
Informed consent statement: For the characteristics of retrospective study, formal written consent is not applicable.
Conflict-of-interest statement: The author declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email address. Participants informed consent was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Wen, MD, Chief Doctor, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310000, Zhejiang Province, China. 13989454104@163.com
Received: April 25, 2021
Peer-review started: April 25, 2021
First decision: June 3, 2021
Revised: June 5, 2021
Accepted: August 27, 2021
Article in press: August 27, 2021
Published online: October 14, 2021
Core Tip

Core Tip: Synchronous liver metastasis (SLM) indicates poor prognosis for colorectal cancer. Nearly 50% of colorectal cancer patients develop hepatic metastasis, with 15%-25% of them presenting with SLM. It is beneficial to detect the response of SLM to chemotherapy. Magnetic resonance imaging-radiomics could provide a non-invasive approach to predict the risk of SLM. The logistic model of DWI sequence behaved the best in evaluating the chemotherapeutic response in SLM compared with T2WI, DWI, and portal phase of contrast-enhanced sequences. Moreover, the radiomics-clinical nomogram containing radiomics score, CA19-9, and clinical N staging is more effective in predicting the chemotherapeutic response of SLM patients.