Published online Sep 21, 2021. doi: 10.3748/wjg.v27.i35.5932
Peer-review started: March 22, 2021
First decision: June 14, 2021
Revised: June 27, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: September 21, 2021
Core Tip: A few small, heterogeneous, retrospective studies have attempted to determine the optimal treatment for gastric diffuse large B-cell lymphoma, investigating the role of chemotherapy +/- rituximab, surgery and radiation in patient outcomes. Our retrospective research suggests that a better outcome is observed for these patients after the introduction of immunochemotherapy (rituximab-cyclophosphamide doxorubicin vincristine prednisone). Because statistical analysis might differ among various studies, it is crucial to correctly define the terms freedom from progression and lymphoma-specific survival. The latter provides information on whether the patients died from lymphoma or from other causes.