Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2021; 27(3): 255-266
Published online Jan 21, 2021. doi: 10.3748/wjg.v27.i3.255
Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B
Cai-Zhi Huang, Jie Zhang, Lin Zhang, Cui-Hua Yu, Yi Mo, Li-Ya Mo
Cai-Zhi Huang, Jie Zhang, Lin Zhang, Yi Mo, Li-Ya Mo, Department of Laboratory Medicine, Hunan Children’s Hospital, Changsha 410007, Hunan Province, China
Cui-Hua Yu, Department of GCP Certified Sites, The Third Hospital of Changsha City, Changsha 410005, Hunan Province, China
Author contributions: All authors contributed to the conceptualization of the study; Mo LY designed the research; Huang CZ and Zhang J performed the research; Zhang L and Yu CH contributed to data collection; Huang CZ and Mo Y analyzed the data; Huang CZ and Mo LY wrote and revised the paper.
Supported by Hunan Provincial Health Commission Science Foundation of China, No. 20200017.
Institutional review board statement: This research was reviewed and approved by Ethics Committee of Hunan Children’s Hospital.
Informed consent statement: Informed consent was obtained from all subjects.
Conflict-of-interest statement: All authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Li-Ya Mo, MBBS, Chief Technician, Director, Professor, Department of Laboratory Medicine, Hunan Children's Hospital, No. 86 Ziyuan Road, Changsha 410007, Hunan Province, China.
Received: November 4, 2020
Peer-review started: November 4, 2020
First decision: December 24, 2020
Revised: December 29, 2020
Accepted: January 6, 2021
Article in press: January 6, 2021
Published online: January 21, 2021
Core Tip

Core Tip: Serum vitamin D and vitamin-D-binding protein (VDBP) levels are associated with hepatitis B. The association of vitamin D and VDBP with hepatitis B virus replication and hepatic fibrosis in children with chronic hepatitis B (CHB) has rarely been reported. We found that low level of serum 25-hydroxy vitamin D is an independent factor associated with development of hepatic fibrosis, and it could be valuable for maintaining sufficient 25-hydroxy vitamin D level to prevent or delay hepatic fibrosis in children with CHB. VDBP is negatively correlated with hepatitis B virus replication, and VDBP analogs might be considered for management of CHB.