Published online Jul 28, 2021. doi: 10.3748/wjg.v27.i28.4484
Peer-review started: January 31, 2021
First decision: March 29, 2021
Revised: April 9, 2021
Accepted: July 12, 2021
Article in press: July 12, 2021
Published online: July 28, 2021
Core Tip: Approximately 10% of asymptomatic subjects with normal blood tests have small intestinal mucosal breaks. A reanalysis of our previous studies showed that small intestinal mucosal breaks were strongly correlated with body mass index, were significantly more prevalent in Helicobacter pylori-infected individuals and were more prevalent in men. These may be risk factors for small intestinal mucosal breaks. Overall, 1-2 small ulcerative lesions in asymptomatic patients are considered to be in the normal range and do not require close examination, and it is assumed that a follow-up medical examination is required.