Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2021; 27(26): 3951-3970
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.3951
Liver dysfunction and SARS-CoV-2 infection
Abraham Edgar Gracia-Ramos, Joel Omar Jaquez-Quintana, Raúl Contreras-Omaña, Moises Auron
Abraham Edgar Gracia-Ramos, Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico
Joel Omar Jaquez-Quintana, Gastroenterology Service and Department of Internal Medicine, Faculty of Medicine, University Hospital "Dr. José E. González”, Universidad Autónoma de Nuevo León, Monterrey 64460, Mexico
Raúl Contreras-Omaña, Centro de Estudio e Investigación en Enfermedades Hepáticas y Toxicológicas (CEIHET), Pachuca 42184, Mexico
Moises Auron, Departments of Hospital Medicine and Pediatric Hospital Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: The authors contributed equally to all aspects of this manuscript preparation and have read and approved the final manuscript; each author meets the criteria for authorship established by the International Committee of Medical Journal Editors.
Conflict-of-interest statement: The authors declare having no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Abraham Edgar Gracia-Ramos, MD, MSc, Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P., Mexico City 02990, Mexico.
Received: March 16, 2021
Peer-review started: March 16, 2021
First decision: May 1, 2021
Revised: May 9, 2021
Accepted: June 16, 2021
Article in press: June 16, 2021
Published online: July 14, 2021
Core Tip

Core Tip: Coronavirus disease 2019 (COVID-19)-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease, with an observed ratio of 1:5. The presence of abnormal liver biochemical parameters has been associated with a severe course of severe acute respiratory syndrome coronavirus 2 infection and other complications, including death. Pathophysiology of COVID-19-induced liver injury is complex. Also, special consideration should be made in patients with pre-existing liver disease, such as metabolic dysfunction-associated fatty liver disease, chronic liver disease due to viral or autoimmune disease, liver transplant carriers, or cirrhosis.