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World J Gastroenterol. Jul 7, 2021; 27(25): 3790-3801
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3790
Human immune repertoire in hepatitis B virus infection
Qiao Zhan, Jing-Hang Xu, Yan-Yan Yu, Emily Lo KK, Felicianna, Hani El-Nezami, Zheng Zeng
Qiao Zhan, Jing-Hang Xu, Yan-Yan Yu, Zheng Zeng, Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
Emily Lo KK, Felicianna, Hani El-Nezami, School of Biological Sciences, University of Hong Kong, Hong Kong, China
Hani El-Nezami, Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio FI-70211, Finland
Author contributions: Zhan Q and Xu JH wrote the paper; Yu YY, Lo KK E, Felicianna collected the data; El-Nezami H and Zeng Z revised the paper. Zhan Q and Xu JH equally contributed to the manuscript.
Supported by The National Natural Science Foundation of China, No. 61972007 and No. 30671855; the International Science & Technology Cooperation Program of China, No. 2014DFR31200; and Ministry of Science and Technology of China, No. 2017ZX10202202.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng Zeng, MD, PhD, Chief Physician, Department of Infectious Diseases, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. zeng@bjmu.edu.cn
Received: January 25, 2021
Peer-review started: January 25, 2021
First decision: February 27, 2021
Revised: March 8, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: July 7, 2021
Core Tip

Core Tip: A Hepatitis B virus (HBV) cure depends on activation of the anti-HBV adaptive immune system. Immune repertoire sequencing is a novel method to investigate all aspects of the human adaptive immune system. However, the immune repertoire in HBV infection is still not clear. We review the immune repertoire analysis methodology and provide a new insight into outcomes of HBV infection and vaccination.