Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2021; 27(23): 3386-3395
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3386
Preliminary prospective study of real-time post-gastrectomy glycemic fluctuations during dumping symptoms using continuous glucose monitoring
Motonari Ri, Souya Nunobe, Satoshi Ida, Naoki Ishizuka, Shinichiro Atsumi, Rie Makuuchi, Koshi Kumagai, Manabu Ohashi, Takeshi Sano
Motonari Ri, Souya Nunobe, Satoshi Ida, Shinichiro Atsumi, Rie Makuuchi, Koshi Kumagai, Manabu Ohashi, Takeshi Sano, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Naoki Ishizuka, Clinical Trial Planning and Management, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Author contributions: Ri M, Nunobe S, Ida S, Kumagai K, Ohashi M and Sano T designed this study; Ri M, Ida S and Atsumi S acquired data; Ri M prepared the final database; Ri M, Nunobe S and Ida S undertook the statistical analysis; Ishizuka N supervised the statistical analysis; Ri M wrote the draft paper; all authors critically reviewed and gave final approval of the version to be published.
Institutional review board statement: This study was approved by the institutional review board in the Cancer Institute Hospital (No. 2017-1110).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have no financial relationships with a commercial entity producing health-care related products and/or services relevant to this article.
Data sharing statement: Technical appendix, statistical code and dataset available from the corresponding author at souya.nunobe@jfcr.or.jp. Participants gave informed consent for data sharing. No additional data are available.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Souya Nunobe, MD, PhD, Director, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan. souya.nunobe@jfcr.or.jp
Received: December 25, 2020
Peer-review started: December 25, 2020
First decision: February 28, 2021
Revised: April 14, 2021
Accepted: May 22, 2021
Article in press: May 22, 2021
Published online: June 21, 2021
Core Tip

Core Tip: Glucose variability at dumping onset was investigated using continuous glucose monitoring and subject diaries after standard gastrectomy for gastric cancer. Postprandial glycemic changes suggest both early and late dumping symptoms. Glycemic profiles during dumping may differ depending on reconstruction methods after gastrectomy, considering the similar glucose fluctuation curves with both early and late dumping after distal gastrectomy with Billroth I reconstruction and rapidly decreasing glucose profiles with late dumping after distal and total gastrectomy, both with Roux-en-Y reconstruction.