Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2021; 27(2): 189-207
Published online Jan 14, 2021. doi: 10.3748/wjg.v27.i2.189
Development of a computed tomography-based radiomics nomogram for prediction of transarterial chemoembolization refractoriness in hepatocellular carcinoma
Xiang-Ke Niu, Xiao-Feng He
Xiang-Ke Niu, Xiao-Feng He, Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Xiang-Ke Niu, Department of Interventional Radiology, Affiliated Hospital of Chengdu University, Chengdu 610081, Sichuan Province, China
Author contributions: He XF designed the research study; He XF and Niu XK performed the research; Niu XK analyzed the data; Niu XK and He XF wrote the paper; all authors have read and approved the final manuscript.
Supported by Health and Family Planning Commission of Sichuan Province, China, No. 17PJ430 and No. 18PJ150.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Affiliated Hospital of Chengdu University, approval No. PJ2019-019-01.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiao-Feng He, MD, Chief Doctor, Professor, Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China.
Received: November 2, 2020
Peer-review started: November 2, 2020
First decision: December 3, 2020
Revised: December 7, 2020
Accepted: December 16, 2020
Article in press: December 16, 2020
Published online: January 14, 2021
Core Tip

Core Tip: At present, it is still difficult to predict transarterial chemoembolization (TACE) refractoriness. The main finding of this study is that our computed tomography (CT)-based radiomics nomogram can be used to individually predict patients’ refractory state before the first session of TACE. The predictive calibration curves of the training and validation datasets demonstrated agreement with the ideal curve. This CT-based radiomics nomogram may provide an unprecedented opportunity to improve clinical decision making for the patients who are repeatedly treated by TACE and, eventually, improve the overall survival of these patients.