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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2021; 27(19): 2341-2352
Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2341
Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2341
Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19
Byungchang Jin, Rajan Singh, Se Eun Ha, Hannah Zogg, Seungil Ro, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, United States
Paul J Park, Department of Medicine, Renown Health, Reno, NV 89557, United States
Author contributions: Jin B, Singh R and Ro S conceived the study; Jin B and Singh R drafted the original manuscript and are joint first authors; Jin B, Singh R, Ha SE, Zogg H, Park PJ, and Ro S revised the manuscript and approved the submitted version.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seungil Ro, PhD, Associate Professor, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Building L-207E, 1664 North Virginia Street, Reno, NV 89557, United States. sro@med.unr.edu
Received: January 29, 2021
Peer-review started: January 29, 2021
First decision: March 6, 2021
Revised: March 17, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: May 21, 2021
Peer-review started: January 29, 2021
First decision: March 6, 2021
Revised: March 17, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: May 21, 2021
Core Tip
Core Tip: Since the declaration of the pandemic on March 11, 2020 by the World Health Organization, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has quickly become a global health threat. In addition to respiratory symptoms, gastrointestinal (GI) symptoms have been widely observed in coronavirus disease 2019 (COVID-19) patients. Here, we have summarized the GI symptoms seen in COVID-19 patients that have been reported in nineteen studies and recapitulated potential mechanisms that are responsible for the GI symptoms in COVID-19 patients. This biochemical understanding may assist in new therapeutic approaches.