Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2341
Peer-review started: January 29, 2021
First decision: March 6, 2021
Revised: March 17, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: May 21, 2021
Core Tip: Since the declaration of the pandemic on March 11, 2020 by the World Health Organization, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has quickly become a global health threat. In addition to respiratory symptoms, gastrointestinal (GI) symptoms have been widely observed in coronavirus disease 2019 (COVID-19) patients. Here, we have summarized the GI symptoms seen in COVID-19 patients that have been reported in nineteen studies and recapitulated potential mechanisms that are responsible for the GI symptoms in COVID-19 patients. This biochemical understanding may assist in new therapeutic approaches.