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World J Gastroenterol. May 21, 2021; 27(19): 2299-2311
Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2299
Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review
Paul Calame, Gaëlle Tyrode, Delphine Weil Verhoeven, Sophie Félix, Anne Julia Klompenhouwer, Vincent Di Martino, Eric Delabrousse, Thierry Thévenot
Paul Calame, Eric Delabrousse, Department of Radiology, Jean Minjoz University Hospital, Besançon 25030, France
Gaëlle Tyrode, Delphine Weil Verhoeven, Vincent Di Martino, Thierry Thévenot, Department of Hepatology, Jean Minjoz University Hospital, Besançon 25030, France
Sophie Félix, Department of Pathology, Jean Minjoz University Hospital, Besançon 25000, France
Anne Julia Klompenhouwer, Department of Surgery, Erasmus University Medical Center, Rotterdam PO Box 2040, The Netherlands
Author contributions: Thévenot T designed the research; Thévenot T, Calame P, and Félix S analyzed the data; Thévenot T, Calame P and Tyrode G wrote the paper; Thévenot T and Calame P made critical revisions related to important content of the revised manuscript; Weil Verhoeven D, Klompenhouwer AJ, Di Martino V, Delabrousse E and Thévenot T provided the final approval of the version to be published.
Conflict-of-interest statement: No conflicts of interest exist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Thierry Thévenot, PhD, Professor, Department of Hepatology, Jean Minjoz University Hospital, 3 Boulevard A. Fleming, Besançon 25030, France. tthevenot@chu-besancon.fr
Received: October 27, 2020
Peer-review started: October 27, 2020
First decision: December 18, 2020
Revised: December 31, 2020
Accepted: March 18, 2021
Article in press: March 18, 2021
Published online: May 21, 2021
Core Tip

Core Tip: Hepatic angiomyolipoma (HAML) is a rare, but not exceptional, mesenchymal liver tumor. HAML contains variable proportions of blood vessels, smooth muscle cells and adipose tissue, which renders its radiological diagnosis challenging. In most cases, this tumor follows a benign clinical course but more aggressive behavior may complicate management, which remains poorly codified. This review presents the main demographic and histological characteristics of HAML, summarizes reported cases of HAML with spontaneous rupture and aggressive behavior, and finally proposes a pragmatic algorithm for the management of HAML based on the most recent knowledge.