Published online Apr 7, 2021. doi: 10.3748/wjg.v27.i13.1296
Peer-review started: January 18, 2021
First decision: February 9, 2021
Revised: February 17, 2021
Accepted: March 19, 2021
Article in press: March 19, 2021
Published online: April 7, 2021
Core Tip: The clinical menace of coronavirus disease 2019 (COVID-19)-related comorbidities of hepatic diseases and severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) tropism for the liver result in liver impairment with increased liver injury markers and cytokine storm. SARS-CoV-2 aggravates liver injury via coagulative and fibrinolytic pathways, cytokine-mediated liver injury, ischemia-hypoxia, and immune-mediated cell death pathways owing to adverse outcomes of liver disease such as nonalcoholic steatohepatitis, drug-induced liver injury, nonalcoholic fatty liver disease, metabolic associated fatty liver disease, and hepatocellular carcinoma. This review summarizes diagnostic approaches, therapeutics, clinical guidelines, and vaccines for COVID-19 and liver disease comorbidities.