Kumar R, Priyadarshi RN, Anand U. Chronic renal dysfunction in cirrhosis: A new frontier in hepatology. World J Gastroenterol 2021; 27(11): 990-1005 [PMID: 33776368 DOI: 10.3748/wjg.v27.i11.990]
Corresponding Author of This Article
Ramesh Kumar, MD, Associate Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, Bihar, India. docrameshkr@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Frontier
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ramesh Kumar, Department of Gastroenterology, All India Institute of Medical Sciences, Patna 801507, Bihar, India
Rajeev Nayan Priyadarshi, Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna 801507, Bihar, India
Utpal Anand, Department of Surgical Gastroenterology, All India Institute of Medical Sciences, Patna 801507, Bihar, India
Author contributions: Kumar R designed and wrote the manuscript, and collected relevant data; Priyadarshi RN and Anand U contributed in data collection and manuscript writing; all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramesh Kumar, MD, Associate Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, Bihar, India. docrameshkr@gmail.com
Received: December 24, 2020 Peer-review started: December 24, 2020 First decision: January 10, 2021 Revised: January 17, 2021 Accepted: March 8, 2021 Article in press: March 8, 2021 Published online: March 21, 2021
Core Tip
Core Tip: The current definition of chronic kidney disease (CKD) in patients with liver cirrhosis is based on a 3-mo decline in the glomerular filtration rate of < 60 mL/min, and it may be structural or functional CKD, depending on the presence or absence of kidney injury. Emerging data show that the incidence of CKD has risen dramatically in patients with cirrhosis over the last decade. The main reasons behind the increased prevalence of CKD appear to be a growing recognition of this condition and a rising trend in the prevalence of diabetes, hypertension and nonalcoholic fatty liver disease. This paper offers a detailed overview of CKD in patients with cirrhosis, including the clinical implications and difficulties clinicians may face with regard to diagnosis and treatment.
