Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.990
Peer-review started: December 24, 2020
First decision: January 10, 2021
Revised: January 17, 2021
Accepted: March 8, 2021
Article in press: March 8, 2021
Published online: March 21, 2021
Core Tip: The current definition of chronic kidney disease (CKD) in patients with liver cirrhosis is based on a 3-mo decline in the glomerular filtration rate of < 60 mL/min, and it may be structural or functional CKD, depending on the presence or absence of kidney injury. Emerging data show that the incidence of CKD has risen dramatically in patients with cirrhosis over the last decade. The main reasons behind the increased prevalence of CKD appear to be a growing recognition of this condition and a rising trend in the prevalence of diabetes, hypertension and nonalcoholic fatty liver disease. This paper offers a detailed overview of CKD in patients with cirrhosis, including the clinical implications and difficulties clinicians may face with regard to diagnosis and treatment.