Published online Nov 14, 2020. doi: 10.3748/wjg.v26.i42.6556
Peer-review started: August 29, 2020
First decision: September 12, 2020
Revised: September 24, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: November 14, 2020
Core Tip: In addition to the adenoma to carcinoma transition, colorectal carcinogenesis can also occur via the serrated pathway. In most serrated polyps, the pathway is believed to include the acquisition of a mutation in a gene that regulates mitogen-activated protein kinase (MAPK) pathway, disruptions to the Wnt signaling pathway and widespread methylation of CpG islands. Moreover, there are less data about different microRNAs (miRNAs) expression profiling in serrated adenomas with different grades of dysplasia. In contrast to the conventional colorectal carcinogenesis, the pivotal role of miRNAs and their relevant signaling pathways in the serrated pathway of carcinogenesis is still to be elucidated because of an insufficient number of studies conducted to clarify separate steps in the process.