Published online Nov 7, 2020. doi: 10.3748/wjg.v26.i41.6322
Peer-review started: June 18, 2020
First decision: July 28, 2020
Revised: August 22, 2020
Accepted: October 1, 2020
Article in press: October 1, 2020
Published online: November 7, 2020
Core Tip: Gastroesophageal reflux (GER) is common in patients with cystic fibrosis (CF) and is often regarded as playing a role in the pathogenesis of CF lung disease. Several studies have showed that patients with CF who have coexisting GER have more severe pulmonary disease with an increased numbers of infectious exacerbations as well as a lower pulmonary function. An adequate diagnostic and therapeutic management can significantly improve respiratory morbidity. Because of the lack of specific guidelines for management of GER in CF, currently, diagnosis and treatment for symptomatic GER in CF patients is based on standard guidelines for the general population. Herein, we aimed to provide a pragmatic update on the pathophysiology, diagnostic work-up, and therapeutic options in the GERD patients with CF.