Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2020; 26(35): 5272-5286
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5272
New approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis induced by dextran sodium sulfate
Mi-Rae Shin, Hae-Jin Park, Bu-Il Seo, Seong-Soo Roh
Mi-Rae Shin, Bu-Il Seo, Seong-Soo Roh, Department of Herbology, Korean Medicine College, Daegu Haany University, Suseong-gu, Deagu 42158, South Korea
Hae-Jin Park, DHU Bio Convergence Testing Center, Gyeongsan-si, Gyeongsangbuk-do 38610, South Korea
Author contributions: Shin MR performed the majority of experiments and wrote the paper; Park HJ and Seo BI analyzed the data; Roh SS designed and coordinated the research.
Supported by Traditional Korean Medicine R&D Program funded by the Ministry of Health & Welfare through the Korea Health Industry Development Institute (KHIDI), No. HI15C00255; and National Research Foundation of Korea (NRF) funded by the Korean government (MSIP), No. 2018R1A5A2025272.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Daegu Haany University (No. DHU2017-043).
Conflict-of-interest statement: The authors declare no competing financial interests related to this study or its publication.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Seong-Soo Roh, PhD, Director, Professor, Department of Herbology, Korean Medicine College, Daegu Haany University, 136 Shinchendong–ro, Suseong-gu, Deagu 42158, South Korea.
Received: April 1, 2020
Peer-review started: April 1, 2020
First decision: April 25, 2020
Revised: April 29, 2020
Accepted: August 25, 2020
Article in press: August 25, 2020
Published online: September 21, 2020
Core Tip

Core Tip: Sulfasalazine has been used widely as a standard-of-care in ulcerative colitis; however, it is associated with a spectrum of side effects after long-term and high-dose intake. Since a single dose of sulfasalazine cannot provide satisfactory therapeutic results, we conducted a comparative evaluation of the pharmacological effect of sulfasalazine alone and when used in combination with Citrus unshiu peel and Bupleuri radix mixture in an experimentally-induced ulcerative colitis mouse model.