Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2020; 26(34): 5181-5206
Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5181
Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review
Rani Kanthan, Suresh Tharmaradinam, Tehmina Asif, Shahid Ahmed, Selliah C Kanthan
Rani Kanthan, Suresh Tharmaradinam, Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon S7N 0W8, SK, Canada
Tehmina Asif, Shahid Ahmed, Division of Oncology, Saskatoon Cancer Centre, Saskatoon S7N 0W8, SK, Canada
Selliah C Kanthan, Division of General Surgery, University of Saskatchewan, Saskatoon S7N 0W8, SK, Canada
Author contributions: All authors made a substantial contribution to the concept, design, acquisition of data and manuscript writing. Each author has participated sufficiently in the work to take public responsibility for the appropriate portions of the content. Preliminary drafts and revisions were undertaken for review of intellectual content and the final version is approved by all authors prior to submission for publication.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
PRISMA 2009 Checklist statement: The guidelines of the PRISMA 2009 statement have been adapted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Suresh Tharmaradinam, MD, Department of Pathology and Laboratory Medicine, University of Saskatchewan, Royal University Hospital 2839 - 103 Hospital Dr, Saskatoon S7N 0W8, SK, Canada.
Received: May 22, 2020
Peer-review started: May 22, 2020
First decision: June 13, 2020
Revised: June 18, 2020
Accepted: August 20, 2020
Article in press: August 20, 2020
Published online: September 14, 2020
Core Tip

Core Tip: This seminal manuscript provides a targeted review of these complex, rare neoplasms of the colon and rectum that should interest colorectal pathologists, surgeons, oncologists and gastroenterologists. This targeted review chronicles the evolution over time with summarization of historical perspectives of terminology with a proposal for a new-innovative, clinically-relevant, simple, non-ambiguous terminology for these lesions as mixed epithelial endocrine neoplasms. The pathogenesis including genomic landscape, clinico-radio-pathological features, treatment and prognosis, with gaps in knowledge are discussed. In keeping with our philosophy of a multidisciplinary management of these tumors, this manuscript has a multidisciplinary team (pathologists, oncologist and surgeon) of authorship.