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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2020; 26(33): 4983-4995
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4983
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4983
Acute liver failure and death predictors in patients with dengue-induced severe hepatitis
Tongluk Teerasarntipan, Roongruedee Chaiteerakij, Piyawat Komolmit, Sombat Treeprasertsuk, Department of Medicine, Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University, and Thai Red Cross, Bangkok 10330, Thailand
Pisit Tangkijvanich, Department of Biochemistry, Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Author contributions: Teerasarntipan T designed the study, collected information, analysed data and drafted the manuscript, and was involved in data collection; Chaiteerakij R, Komolmit P, and Tangkijvanich P assisted in manuscript draft; Treeprasertsuk S oversight the study, contributed to data analysis and assisted in manuscript draft; all authors read and approved the final manuscript.
Supported by the Fatty Liver Unit, Foundation of the Faculty of Medicine, Chulalongkorn University .
Institutional review board statement: This study was approved by the Institutional Review Board of the Faculty of Medicine, Chulalongkorn University (IRB. No. 326/63).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
Data sharing statement: Not available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sombat Treeprasertsuk, MD, PhD, Doctor, Professor, Department of Medicine, Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University, and Thai Red Cross, No. 1873 Rama 4 Road, Pathumwan District, Bangkok 10330, Thailand. sombat.t@chula.ac.th
Received: May 15, 2020
Peer-review started: May 15, 2020
First decision: June 4, 2020
Revised: June 17, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: September 7, 2020
Peer-review started: May 15, 2020
First decision: June 4, 2020
Revised: June 17, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: September 7, 2020
Core Tip
Core tip: Acute liver failure (ALF) from dengue infection is rare, but it results in high mortality rate not only due to impairment in synthesis and detoxification functions of the liver but also because ALF indicates a state of severe inflammatory response to dengue; hence, early identification of patients who are at risk of ALF and prompt treatment are keys to improving clinical outcomes. Both Model for End-Stage Liver Disease (MELD) score and international normalized ratio (INR) level were excellent prognostic predictors for dengue patients with severe hepatitis. MELD score was the best predictor of ALF, while baseline INR level was the best predictors of mortality.