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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2020; 26(32): 4846-4856
Published online Aug 28, 2020. doi: 10.3748/wjg.v26.i32.4846
Published online Aug 28, 2020. doi: 10.3748/wjg.v26.i32.4846
Current status of Helicobacter pylori eradication and risk factors for eradication failure
Tian-Lian Yan, Jian-Guo Gao, Jing-Hua Wang, Dan Chen, Chao Lu, Cheng-Fu Xu, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Yan TL and Gao JG contributed equally to this work; Xu CF, Yan TL, and Lu C designed the research; Yan TL, Gao JG, and Chen D performed the research; Wang JH analyzed the data; Yan TL and Xu CF drafted and revised the manuscript. All authors approved the final draft of this manuscript for submission.
Supported by the National Natural Science Foundation of China , No. 81600447 .
Institutional review board statement: This study was reviewed and approved by the Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine.
Informed consent statement: Because of the retrospective and anonymous nature of this study, the need for informed consent was exempted by the institutional review board.
Conflict-of-interest statement: All of the authors declare that they have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cheng-Fu Xu, MD, Doctor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaofu@zju.edu.cn
Received: April 24, 2020
Peer-review started: April 24, 2020
First decision: June 13, 2020
Revised: July 18, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 28, 2020
Peer-review started: April 24, 2020
First decision: June 13, 2020
Revised: July 18, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 28, 2020
Core Tip
Core tip: The Helicobacter pylori eradication rate is decreasing worldwide, and there is a lack of recent data from China. The current study of 14-d quadruple regimens in Eastern China revealed an eradication rate of 76.6%. Amoxicillin-containing regimens had the highest eradication rate in primary therapy, and amoxicillin- and furazolidone-containing regimens showed superiority in rescue therapy. Age, prior therapy, and use of omeprazole or pantoprazole were independent risk factors for eradication failure. This study can improve the choice of antibiotics and proton pump inhibitors and indicates that in clinical practice, attention should be paid to elderly patients and rescue therapy.