Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4567
Peer-review started: June 4, 2020
First decision: June 18, 2020
Revised: June 22, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 21, 2020
Core tip: Perturbation of micronutrients has been broadly reported to be a common characteristic in patients with alcoholic liver disease (ALD). In the current study, we provide a review of recent studies that investigated the imbalance of micronutrients in patients with ALD with a focus on zinc, iron, copper, magnesium, selenium, vitamin D and vitamin E, and determine how disturbances in micronutrients relates to the pathophysiology of ALD. More importantly, we also highlight several challenges in terms of low sample size, study design discrepancies, sample heterogeneity across studies, and the use of machine learning approaches.