Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2020; 26(28): 4094-4107
Published online Jul 28, 2020. doi: 10.3748/wjg.v26.i28.4094
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo, Cheng-Wei Tang
Wei Su, Cheng-Wei Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Wei Su, Bi-Guang Tuo, Department of Gastroenterology, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Cheng-Wei Tang, Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Tang CW and Gao JH designed and coordinated the study; Su W, Tai Y, Tang SH, Ye YT, and Zhao C performed the experiments and acquired and analyzed the data; Su W and Tang CW interpreted the data; Tuo BG provide technical assistance; Su W wrote the manuscript; Tang CW reviewed the manuscript, all authors approved the final version of the article.
Supported by the National Natural Science Fund of China, No. U1702281, No. 81670551, and No. 81873584.
Institutional animal care and use committee statement: The animal procedures were approved by the Animal Use and Care Committee of Sichuan University and were conducted according to regulations formulated by Sichuan University (Licence No. 2017005A).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this manuscript.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Cheng-Wei Tang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China.
Received: January 30, 2020
Peer-review started: January 30, 2020
First decision: April 22, 2020
Revised: May 21, 2020
Accepted: June 25, 2020
Article in press: June 25, 2020
Published online: July 28, 2020
Core Tip

Core tip: This study aimed to explore the important role of celecoxib in modulating hepatocyte apoptosis during the development of liver fibrosis, and to clarify that the mechanism of its regulation is mediated by endoplasmic reticulum stress, which in turn affects the progression of liver fibrosis. We concluded that therapeutic administration of celecoxib can effectively reduce hepatic apoptosis in thioacetamide-induced cirrhotic rats. The mechanism of action may be attributed to the suppression of CCAAT/enhancer binding protein homologous protein expression, which subsequently inhibits endoplasmic reticulum stress.