Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2020; 26(25): 3638-3649
Published online Jul 7, 2020. doi: 10.3748/wjg.v26.i25.3638
Functionality is not an independent prognostic factor for pancreatic neuroendocrine tumors
Hong-Yu Chen, Ya-Liang Zhou, Yong-Hua Chen, Xing Wang, Hao Zhang, Neng-Wen Ke, Xu-Bao Liu, Chun-Lu Tan
Hong-Yu Chen, Ya-Liang Zhou, Yong-Hua Chen, Xing Wang, Hao Zhang, Neng-Wen Ke, Xu-Bao Liu, Chun-Lu Tan, Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Chen HY and Zhou YL contributed equally to this work; Liu XB, Tan CL, and Wang X designed the study; Chen HY, Zhou YL, Wang X, and Zhang H acquired the data; Chen HY, Zhou YL, and Wang X analyzed and interpreted the data; Chen HY and Zhou YL wrote the paper; Liu XB, Tan CL, and Chen YH critically revised the manuscript for important intellectual content; all authors have read and approved the version to be submitted.
Supported by 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, China, No. ZY2017302 1-3-5; and the Key Research and Development Projects of Sichuan Province, China, No. 2017SZ0132 and No. 2019YFS0042.
Institutional review board statement: This study was reviewed and approved by the West China Hospital Review Board.
Informed consent statement: Study participants of the West China Hospital database provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Chun-Lu Tan, MD, Associate Professor, Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China.
Received: January 10, 2020
Peer-review started: January 10, 2020
First decision: March 6, 2020
Revised: May 8, 2020
Accepted: June 9, 2020
Article in press: June 9, 2020
Published online: July 7, 2020
Core Tip

Core tip: Pancreatic neuroendocrine tumors (pNETs) are classified into functional and nonfunctional tumors according to the existence of hormones related symptoms or not. The traditional view is that functionality is correlated with the prognosis of pNET patients, which remains a controversial opinion. In this study, we retrospectively analyzed the clinicopathological data of 426 patients from the Surveillance, Epidemiology, and End Results database and 205 patients from the West China Hospital database. The results indicated that functionality is not associated with prognosis. Race, age, sex, and T stage are independent factors for predicting the survival of patients with pNETs.