Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2020; 26(23): 3260-3270
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3260
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3260
Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after acute pancreatitis: A long-term follow-up study
Bing-Jun Yu, Nian-Shuang Li, Wen-Hua He, Cong He, Jian-Hua Wan, Yin Zhu, Nong-Hua Lu, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Yu BJ conceptualized and designed the study and wrote the manuscript; Yu BJ and Li NS collected the data; He WH made critical revisions to the manuscript; Wan JH and He C helped in interpreting and analyzing the data; Zhu Y and Lu NH made substantial contributions to the conception, design, and coordination of the study and gave final approval of the version to be published; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81860122 .
Institutional review board statement: This study was approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University.
Informed consent statement: All involved subjects gave their informed consent (written or verbal) prior to study inclusion.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Nong-Hua Lu, MD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China. lunonghua@ncu.edu.cn
Received: January 22, 2020
Peer-review started: January 22, 2020
First decision: February 27, 2020
Revised: March 29, 2020
Accepted: May 15, 2020
Article in press: May 15, 2020
Published online: June 21, 2020
Peer-review started: January 22, 2020
First decision: February 27, 2020
Revised: March 29, 2020
Accepted: May 15, 2020
Article in press: May 15, 2020
Published online: June 21, 2020
Core Tip
Core tip: This is the first research to explore the association between acute pancreatitis and pancreatic endocrine insufficiency in a longer time than before and we included patients who were followed for a long time from 3 mo to 7 years. Furthermore, we found that pancreatic necrosis and severity were independent risk factors for pancreatic endocrine insufficiency after AP. Debridement of necrosis (percutaneous catheter drainage and/or operative necrosectomy) was a protective factor on pancreatic endocrine insufficiency after AP. Our results will provide some guidance on the clinical practice in the future.