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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2020; 26(23): 3145-3169
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3145
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3145
Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis
Elodie Sarron, Maxime Pérot, Nicolas Barbezier, Carine Delayre-Orthez, Pauline M Anton, Transformations and Agroressources (EA 7519), Institut Polytechnique UniLaSalle, Université d'Artois, Beauvais 60026, France
Jérôme Gay-Quéheillard, Périnatalité et risques Toxiques, UMR-I-01, Université de Picardie Jules Verne, Amiens 80000, France
Author contributions: Sarron E contributed to the synthesis of information related to antibiotics and gut homeostasis; Pérot M and Delayre-Orthez C worked on the consequences of environmental factors on the establisment and orientation of immune response in relation to gut homeostasis; Barbezier N worked on the molecular and epigenetic consequences of such alterations; Gay-Quéheillard J worked mainly on brain gut microbiota axis exchanges and Anton PM supervised the overall work and contributed to the final form of the manuscript by completing, synthetizing and linking all the work together.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Pauline M Anton, PhD, Associate Professor, Transformations and Agroressources (EA 7519), Institut Polytechnique UniLaSalle, Université d'Artois, 19 Rue Pierre Waguet, BP 30313, Beauvais 60026, France. pauline.anton@unilasalle.fr
Received: January 31, 2020
Peer-review started: January 31, 2020
First decision: May 1, 2020
Revised: May 12, 2020
Accepted: May 30, 2020
Article in press: May 30, 2020
Published online: June 21, 2020
Peer-review started: January 31, 2020
First decision: May 1, 2020
Revised: May 12, 2020
Accepted: May 30, 2020
Article in press: May 30, 2020
Published online: June 21, 2020
Core Tip
Core tip: Increase of non-communicable chronic disease in the world is now clearly associated to environmental factors exposure during life and more especially during fetal and postnatal life. This review outlines the actual understanding of the consequences, on pregnant women, babies and infants, of repeated exposure to low level food contaminants on the settlement and maturation of the gut with specific focus on gut homeostasis, brain gut axis exchanges and the pivotal role played by the microbiota. However, their exact mechanisms of action on health, and particularly the molecular ones including epigenetic regulations still need to be clarified.