©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus
Karen Chiam, George C Mayne, Tingting Wang, David I Watson, Tanya S Irvine, Tim Bright, Lorelle T Smith, Sarah K Thompson, Damian J Hussey, Discipline of Surgery, College of Medicine and Public Health, Flinders University of South Australia, Adelaide, SA 5042, Australia
Karen Chiam, George C Mayne, Tingting Wang, David I Watson, Tanya S Irvine, Tim Bright, Lorelle T Smith, Damian J Hussey, Flinders Health and Medical Research Institute Cancer Program, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia
Lorelle T Smith, Discipline of Surgery, The University of Adelaide, Adelaide, SA 5005, Australia
Imogen A Ball, Joanne M Bowen, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia
Dorothy M Keefe, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5005, Australia
Author contributions: Hussey DJ conceived and supervised the study; Chiam K, Mayne GC, Watson DI, Bowen JM, Keefe DM, Thompson SK and Hussey DJ contributed to study design; Watson DI, Irvine TS, Bright T, Smith LT and White I collected patient blood samples; Wang T processed patient blood samples and performed the laboratory assays; Chiam K, Mayne GC and Hussey DJ analysed the data; Chiam K wrote the first draft of the paper; All authors contributed to revision of the manuscript in its final version.
Supported by National Health and Medical Research Council (NHMRC) Project Funding, No. APP1104281; and NHMRC Centres of Research Excellence (CRE) Grant, No. APP1040947.
Institutional review board statement: Ethical approval was obtained from the Southern Adelaide Clinical Human Research Ethics Committee and the Royal Adelaide Hospital Research Committee.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Damian J Hussey, PhD, Senior Scientist, Discipline of Surgery, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, Adelaide, SA 5042, Australia. email@example.com
Received: January 1, 2020
Peer-review started: January 1, 2020
First decision: January 19, 2020
Revised: March 2, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020