Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2533
Peer-review started: December 23, 2019
First decision: April 1, 2020
Revised: April 7, 2020
Accepted: April 29, 2020
Article in press: April 29, 2020
Published online: May 28, 2020
Core tip: The nervous mechanisms of gastric mucosal lesion in rats subjected to restraint water-immersion stress were investigated. Abnormal regulation of the enteric nervous system, mainly due to the enhanced activity of the parasympathetic nervous system, can induce gastrointestinal dysfunction. The central nucleus such as dorsal motor nucleus of the vagus, nucleus ambiguous, nucleus of the solitary tract, paraventricular nucleus, supraoptic nucleus, mediodorsal nucleus of the thalamus, central nucleus of the amygdala and medial prefrontal cortex are all involved in the formation of stress-induced gastric mucosal lesion. Nitric oxide, 5-hydroxytryptamine, hydrogen sulfide, calcitonin gene-related peptide, vasoactive intestinal peptide, acetylcholine, catecholamine, glutamate, γ-aminobutyric acid, oxytocin and arginine vasopressin may be involved in the physiological process.