Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2498
Peer-review started: December 30, 2019
First decision: January 19, 2020
Revised: March 27, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020
Core tip: Microbiome and immunity sciences are fields in rapid evolution gaining growing attention. The gut microbiota-immunity interplay seems to have a very important role in all the different phases of colorectal cancer process from oncogenesis to treatment and prognosis. However, many aspects have been studied only in experimental models and many theories must still be proved in humans. Providing the actual state of art of this interplay on the different steps involved in colorectal cancer, new multidisciplinary studies in humans according to this perspective may be drafted with the purpose of widening the possibilities of treatment against this frequently diagnosed pathology.