Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2020; 26(19): 2374-2387
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2374
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2374
Predicting dyslipidemia after liver transplantation: A significant role of recipient metabolic inflammation profile
Hai-Tao Huang, Xue-You Zhang, Cheng Zhang, Qi Ling, Shu-Sen Zheng, Department of Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Qi Ling, Shu-Sen Zheng, Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, Zhejiang Province, China
Author contributions: Ling Q designed the research; Huang HT, Zhang XY, and Zhang C performed the research and analyzed the data; Huang HT wrote the manuscript; Zheng SS and Ling Q reviewed the manuscript; all authors approved the final version of the article.
Supported by the National Natural Science Foundation of China , No. 81771713 ; Zhejiang Provincial Natural Science Foundation of China , No. LR18H030001 .
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital, Zhejiang University School of Medicine Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest to be disclosed.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at lingqi@zju.edu.cn.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qi Ling, MD, PhD, Doctor, Surgeon, Department of Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou 310003, Zhejiang Province, China. lingqi@zju.edu.cn
Received: December 30, 2019
Peer-review started: December 30, 2019
First decision: March 26, 2020
Revised: April 8, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: May 21, 2020
Peer-review started: December 30, 2019
First decision: March 26, 2020
Revised: April 8, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: May 21, 2020
Core Tip
Core tip: Post-transplant dyslipidemia (PTDL) is a common complication in liver recipients and can cause morbidity and threaten graft function. The crosstalk between metabolic inflammation and dyslipidemia has been recently revealed, however, the role of recipients’ metabolic status in the development of PTDL has not been evaluated. Here, we conducted the first study to explore the association of recipients’ metabolic inflammation with PTDL and further evaluate the diagnostic efficacy of metabolic inflammation compounds. Interleukin-12 (p70) was found to be a valid predictor of PTDL and remarkably improve the predictive ability of the clinical model.