Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2020; 26(19): 2333-2348
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2333
Gastroparesis: New insights into an old disease
Paolo Usai-Satta, Massimo Bellini, Olivia Morelli, Francesca Geri, Mariantonia Lai, Gabrio Bassotti
Paolo Usai-Satta, Department of Internal Medicine, Division of Gastroenterology, Brotzu Hospital, Cagliari 09124, Italy
Massimo Bellini, Francesca Geri, Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56122, Italy
Olivia Morelli, Gabrio Bassotti, Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia 06123, Italy
Mariantonia Lai, Gastroenterology Unit, University of Cagliari, Monserrato 09042, Italy
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Paolo Usai-Satta, MD, Attending Doctor, Department of Internal Medicine, Division of Gastroenterology, Brotzu Hospital, Piazza Ricchi 1, Cagliari 09124, Italy.
Received: January 23, 2020
Peer-review started: January 23, 2020
First decision: March 6, 2020
Revised: March 8, 2020
Accepted: May 1, 2020
Article in press: May 1, 2020
Published online: May 21, 2020
Core Tip

Core tip: Gastroparesis has a great impact on the quality of life and a heavy economic burden. Our objective was to consolidate current knowledge on its pathophysiology, diagnosis and therapy. Recent evidence has shown that gastroparesis may be due to intrinsic neuropathy. Diagnostic tests that are validated and available are 99-Technetium scintigraphy, the 13C breath test and the wireless motility capsule. The therapy is varied and related to the severity of the disease. After dietary modification, old and new prokinetics and antiemetics are available. In drug-refractory patients, endoscopic or surgical procedure may be indicated.