Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2020; 26(13): 1525-1539
Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1525
Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1525
Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen ≤ 1500 IU/mL: An observational study
Feng-Ping Wu, Ying Yang, Mei Li, Yi-Xin Liu, Ya-Ping Li, Wen-Jun Wang, Juan-Juan Shi, Xin Zhang, Xiao-Li Jia, Shuang-Suo Dang, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Dang SS participated in study conception and design, study supervision, data interpretation, manuscript editing and funding support; Wu FP conceived and designed the study, collected data, drafted the manuscript, planned the study, analyzed and interpreted data and performed statistical analysis; Yang Y, Li M, Liu YX and Li YP participated in analysis and interpretation of clinical data and consultations in liver disease; Wang WJ and Shi JJ participated in data collection, statistical analysis and drafted the manuscript; Zhang X and Xiao-li Jia XL participated in critical revision of the manuscript, consultations and funding support.
Supported by the National Natural Science Foundation of China , No. 31500650 .
Institutional review board statement: This study was approved by the Institutional Review Board of Xi’an Jiaotong University.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors do not have any conflict of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items and the manuscript was prepared and revised accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuang-Suo Dang, MD, PhD, Academic Fellow, Academic Research, Doctor, Professor, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. dang212@126.com
Received: December 9, 2019
Peer-review started: December 9, 2019
First decision: December 30, 2019
Revised: January 9, 2020
Accepted: March 9, 2020
Article in press: March 9, 2020
Published online: April 7, 2020
Peer-review started: December 9, 2019
First decision: December 30, 2019
Revised: January 9, 2020
Accepted: March 9, 2020
Article in press: March 9, 2020
Published online: April 7, 2020
Core Tip
Core tip: Despite promising results with the combination therapy of Peg-interferon and nucleos(t)ide analog (NA), the best combination therapeutic strategy of Peg-interferon and NA to the treatment of chronic hepatitis B remains unclear. This prospective study was to evaluate the efficacy and safety of adding 48 wk of peginterferon α-2a treatment to an ongoing NA regime in chronic hepatitis B patients with hepatitis B surface antigen levels ≤ 1500 IU/mL, hepatitis B e antigen-negative and hepatitis B virus-deoxyribonucleic acid < 1.0 × 102 IU/mL after over 1 year of NA therapy.