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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2020; 26(12): 1242-1261
Published online Mar 28, 2020. doi: 10.3748/wjg.v26.i12.1242
Published online Mar 28, 2020. doi: 10.3748/wjg.v26.i12.1242
Roles of G protein-coupled receptors in inflammatory bowel disease
Zhen Zeng, Xiao-Li Yang, Sha Chen, Hu Zhang, Department of Gastroenterology, Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu 410061, Sichuan Province, China
Arjudeb Mukherjee, Adwin Pidiyath Varghese, West China School of Medicine, Sichuan University, Chengdu 410061, Sichuan Province, China
Author contributions: Zeng Z and Zhang H outlined the overall manuscript; all authors contributed to the writing of the manuscript; Zhang H supervised the preparation of the draft and edited it; all authors approved the final version.
Supported by National Natural Science Foundation of China , No. 81570502 ; the 1.3.5 Project for Disciplines of Excellence , West China Hospital, Sichuan University, No. ZYJC18037 .
Conflict-of-interest statement: No conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hu Zhang, MD, PhD, Director, Professor, Department of Gastroenterology, Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu 410061, Sichuan Province, China. zhanghu@scu.edu.cn
Received: October 17, 2019
Peer-review started: October 17, 2019
First decision: November 22, 2019
Revised: January 18, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 28, 2020
Peer-review started: October 17, 2019
First decision: November 22, 2019
Revised: January 18, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 28, 2020
Core Tip
Core tip: Inflammatory bowel disease is a complex and heterogeneous disease with unclear pathogenesis. Advances in the understanding of the structures and functions of G protein-coupled receptors (GPCRs) have been a driving force for exploring the roles of GPCRs in the pathogenesis of diseases, thereby leading to the development of GPCR-targeted medication. In this review, we mainly focus on the roles of GPCRs in the pathogenesis of inflammatory bowel disease and their potential values in disease diagnosis, treatment and monitoring.