Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2020; 26(11): 1197-1207
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1197
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies
Ioannis A Voutsadakis
Ioannis A Voutsadakis, Algoma District Cancer Program, Sault Area Hospital, Sault Ste Marie, ON P6B 0A8, Canada
Ioannis A Voutsadakis, Section of Internal Medicine, Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON P0M 2Z0, Canada
Author contributions: Voutsadakis IA designed research, performed research, analyzed data and wrote the paper.
Institutional review board statement: This study was a retrospective analysis of previously published data, available in the public domain, no IRB approval is required.
Informed consent statement: Given that this is a retrospective analysis of previously published, anonymized data, no patient informed consent was required or obtained.
Conflict-of-interest statement: I have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ioannis A Voutsadakis, MD, PhD, Assistant Professor, Doctor, Algoma District Cancer Program, Sault Area Hospital, 750 Great Northern Road, Sault Ste Marie, ON P6B 0A8, Canada.
Received: December 6, 2019
Peer-review started: December 6, 2019
First decision: February 16, 2020
Revised: February 21, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 21, 2020
Core Tip

Core tip: BRIP1 gene alterations are uncommon in gastrointestinal cancers. Mutations frequently occur in hypermutated carcinomas and co-occur with other homologous recombination genes mutations. Despite their rarity, BRIP1 defects may present an opportunity for therapeutic interventions similar to other homologous recombination defects.