Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.521
Peer-review started: December 3, 2018
First decision: December 28, 2018
Revised: January 2, 2019
Accepted: January 9, 2019
Article in press: January 9, 2019
Published online: February 7, 2019
Core tip: Excess iron is observed in several liver pathologies, where it can accelerate the progression of liver fibrosis to cirrhosis and hepatocellular carcinoma, regardless of disease aetiology. This review narrates the role of excess iron in liver fibrosis. It examines the mechanisms by which iron enhances fibrogenic responses and describes various iron-related clinical pathologies. Furthermore, it evaluates the significance of iron and iron-related proteins in the diagnosis and therapeutics of liver fibrosis. The review is unique in that it includes both, cellular mechanisms and clinical aspects of liver fibrosis pertaining to iron. This makes it distinct from previous published reviews.