Direct costs of carcinoid syndrome diarrhea among adults in the United States
Arvind Dasari, Daniel M Halperin, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Vijay N Joish, Raul Perez-Olle, Samyukta Dharba, Kavitha Balaji, Lexicon Pharmaceuticals, Inc., The Woodlands, TX 77381, United States
Author contributions: Dasari A, Joish VN, Perez-Olle R, Dharba S, Balaji K and Halperin DM designed the research; Joish VN and Dharba S analyzed the data; Frimpter J wrote the paper and Dasari A, Joish VN, Perez-Olle R, Dharba S, Balaji K and Halperin DM critically revised all aspects of the manuscript and approved the final version for submission.
Institutional review board statement: We conducted a retrospective cohort study using the IBM® MarketScan® Database, a commercial health insurance claims database for employer-insured beneficiaries in the United States. The database is fully compliant with the Health Insurance Portability and Accountability Act and meets the criteria for a limited-use dataset. Since the patient and provider data included in this analysis were fully de-identified, this study was exempt from the Institutional Review Board review.
Informed consent statement: This study involved analyses of a Health Insurance Portability and Accountability Act-compliant secondary database, the IBM® MarketScan® Database, thus no informed consent was feasible or required.
Conflict-of-interest statement: This study was sponsored by Lexicon Pharmaceuticals, Inc., 8800 Technology Forest Place, The Woodlands, TX 77381, United States. Vijay N Joish, Samkyuta Dharba and Kavitha Balaji are employees of Lexicon Pharmaceuticals, Inc., and Raul Perez-Olle was an employee of Lexicon Pharmaceuticals, Inc. during the conduct of the study and development of the manuscript; they may own common stock or may have been granted stock options or other equity incentive awards. Arvind Dasari and Daniel M Halperin are employees of The University of Texas MD Anderson Cancer Center who received consulting fees from Lexicon Pharmaceuticals, Inc. for their participation and contributions to this study.
Data sharing statement: The statistician for this study, Samyukta Dharba, conducted all statistical analyses using a Health Insurance Portability and Accountability Act-compliant secondary database, the IBM® MarketScan® Database.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Vijay N Joish, PhD, Executive Director, Epidemiology and Outcomes Research, Lexicon Pharmaceuticals, Inc., 110 Allen Road, Basking Ridge, NJ 07920, United States. firstname.lastname@example.org
Received: June 15, 2019
Peer-review started: June 17, 2019
First decision: August 3, 2019
Revised: November 20, 2019
Accepted: November 23, 2019
Article in press: November 23, 2019
Published online: December 21, 2019