Published online Dec 21, 2019. doi: 10.3748/wjg.v25.i47.6799
Peer-review started: August 12, 2019
First decision: September 10, 2019
Revised: November 26, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: December 21, 2019
Core tip: The optimal utilization of organs from hepatitis C (HCV), hepatitis B (HBV) and human immunodeficiency virus (HIV)-positive donors may help attenuate the current organ shortage. Transplantation of organs from patients with HCV viremia to uninfected recipients can be accomplished safely when coupled with the timely initiation of post-transplant direct-acting antiviral therapy. Suppression of HBV with antiviral therapy allows for the safe transplantation from HBV core antibody-positive donors to unexposed recipients, while transplantation of organs from patients who are HBV surface antigen-positive remains investigational. The early experience with HIV-to-HIV positive transplantation via the HOPE act is promising, and allows patients living with HIV improved access to transplantation.