Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2019; 25(43): 6451-6464
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6451
Application of preoperative artificial neural network based on blood biomarkers and clinicopathological parameters for predicting long-term survival of patients with gastric cancer
Si-Jin Que, Qi-Yue Chen, Qing-Zhong, Zhi-Yu Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Si-Jin Que, Qi-Yue Chen, Qing-Zhong, Zhi-Yu Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie, Department of Gastric Surgery and Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Si-Jin Que, Qi-Yue Chen, Qing-Zhong, Zhi-Yu Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie, Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, Fujian Province, China
Si-Jin Que, Qi-Yue Chen, Qing-Zhong, Zhi-Yu Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie, Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou 350108, Fujian Province, China
Author contributions: Que SJ and Chen QY contributed equally to this work. Huang CM, Zheng CH, Chen QY, and Que SJ designed the research; Que SJ, Chen QY, Zhong Q, Liu ZY, Xie JW, Wang JB, Lin JX, Lu J, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Zheng HL, Li P, Zheng CH, and Huang CM performed the research; Que SJ, Chen QY, Zhong Q, and Liu ZY contributed new reagents or analytic tools; Que SJ, Chen QY, Zhong Q, Liu ZY, Huang ZN, Lin JL, Zheng HL, Zheng CH, and Huang CM, Li P analyzed the data; Que SJ, Chen QY, Zhong Q, Liu ZY, Huang CM, and Li P wrote the paper.
Supported by the Scientific and Technological Innovation Joint Capital Projects of Fujian Province, No. 2016Y9031; the Construction Project of Fujian Province Minimally Invasive Medical Center, No. [2017]171; the General Project of Miaopu Scientific Research Fund of Fujian Medical University, No. 2015MP021; the Youth Project of Fujian Provincial Health and Family Planning Commission, No. 2016-1-41; the Fujian Province Medical Innovation Project, Chinese Physicians Association Young Physician Respiratory Research Fund, No. 2015-CXB-16; and the Fujian Science and Technology Innovation Joint Fund Project, No. 2017Y9004.
Institutional review board statement: This retrospective study was approved by the Ethics Committee of Fujian Medical University Union Hospital.
Informed consent statement: The patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jian-Wei Xie, MD, PhD, Doctor, Professor, Department of Gastric Surgery, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Fuzhou 350001, Fujian Province, China. xjwhw2019@163.com
Telephone: +86-591-83363366 Fax: +86-591-83363366
Received: August 19, 2019
Peer-review started: August 19, 2019
First decision: September 10, 2019
Revised: September 17, 2019
Accepted: October 17, 2019
Article in press: October 17, 2019
Published online: November 21, 2019
Core Tip

Core tip: We established an artificial neural network model before surgery that can predict the long-term survival of patients with gastric cancer, and its predictive efficiency is not inferior to that of pathological TNM stage.